Well I feel good now. I started two email conversations with girls at work. One was extremely upset. But unlike yesterday I didn't feel apart of it. It will work out ok i wrote it always does i wrote and it made sense to me at the time but she "no it doesn't" and i wrote you got your body and your mind. but that didn't work so then I........

This a is new and interesting article that explains, among other things, that the detection of CIC's puts the earlier negative studies concerning human borna virus infection into doubt. Some excerpts are below and the free full text is available.

Clin Microbiol Rev. 2003 Jul;16(3):534-45.

Related Articles, Links

=http://cmr.asm.org/cgi/pmidlo...;pmid=12857781" 
Borna disease virus infection, a human mental-health risk.

Bode L, Ludwig H.

Project Bornavirus Infections, Robert Koch Institute, 13353 Berlin, Germany.

As detailed elsewhere (8), CICs(antibody-bound circulating immune complexes (CICs)) represent the prevailing infection marker and are found in more than 90% of patients with a major depressive disorder or bipolar disorder during acute depression.

Long-term follow-up studies of patients are particularly important in major affective disorders because the patients' condition alternates between disease and good health.

changes in the relative amounts of CIC and plasma antigen over time can be monitored precisely and even allow a prognostic estimate, e.g., large plasma antigen amounts correlated significantly with the severity of depression in major depressive disorder and bipolar disorder patients (8), whereas decline of these markers coincided with clinical improvement

The discovery of CICs after years of controversy due to low antibody titers or “disappearing” antibodies explains many previous discrepancies (1, 2, 12, 21, 24, 32, 38, 46, 58). Moreover, the existence of BDV CICs and antigenemia has provided insight into the dynamics of a poorly understood equilibrium of plasma antigen, antibodies, and CICs during persistent BDV infection and its impact on clinical features (9).

Among patients in the acute stage, 40 to 50% had BDV antigen-positive PBMCs in the group of severe cases (4, 8, 9, 22a), and the probability of isolating virus increased considerably with increased disease severity (6). Most of the acutely depressed major depressive disorder and bipolar disorder patients were CIC positive (>90%), and the severity of symptoms correlated with high plasma levels of CIC and antigen (Fig. 1). Among patients of all clinical categories of depression in the study, about 50% were CIC positive (8).

Unlike schizophrenia, major affective disorders (major depressive disorder and bipolar disorder) have become increasingly linked with activated BDV infection.

This abstract proposes that the borna virus effects the 5ht brain system.

Developmental alterations in serotoninergic neurotransmission in Borna disease virus (BDV)-infected rats: a multidisciplinary analysis.

Dietz D, Vogel M, Rubin S, Moran T, Carbone K, Pletnikov M.

Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21205, USA.

Neonatal Borna disease virus (BDV) infection of the rat brain serves as a valuable model for studying the pathogenesis of neurodevelopmental abnormalities following early brain injury. Previous experiments have demonstrated significant alterations in regional tissue content of serotonin (5-HT) in neonatally BDV-infected Lewis rats. The present study sought to provide more insights into postnatal virus-associated alterations in 5-HT neurotransmission by evaluating the density of 5-HT1a receptors in the hippocampus and 5-HT2a receptors in the cortex, regional 5-HT tissue concentrations, behavioral responses to a 5-HT agonist, quipazine, and numbers of neurons in specific subfields of the hippocampus on days 7, 14, and 30 after neonatal BDV infection in Lewis rats. Neonatal BDV infection was found to be associated with a gradual increase in the density of 5-HT2a and 5-HT1a postsynaptic receptors followed by an elevation of 5-HT contents at both the levels of synaptic terminals (i.e., cortex and hippocampus) and cell bodies (i.e., raphe nuclei). In addition, there was an enhanced behavioral response to quipazine. Virus-associated neurochemical and behavioral changes were accompanied by a decline in the number of neurons in the dentate gyrus and in the CA1 field of the hippocampus. No change in the number of neurons in the CA3/2 field of the hippocampus was observed. The present pattern of BDV-associated alterations in 5-HT brain system along with available data from other laboratories suggest that BDV might compromise axonal transport and/or release of 5-HT, resulting in decreased 5-HT neurotransmission.

PMID: 15385249 [PubMed - indexed for MEDLINE]

Here is a meta-analysis that supports the human exposure to Borna Virus

The studies referenced are all dated prior to january 2000.

Borna disease virus and the evidence for human pathogenicity: a systematic review.

Chalmers RM, Thomas DR, Salmon RL.

NPHS Communicable Disease Surveillance Centre, Abton House, Wedal Road, Cardiff CF14 3QX, UK.

BACKGROUND: Borna disease is a neurological viral disease of veterinary importance in central Europe, although Borna Disease virus (BDV) has been reported to be present in animals in most continents. The hypothesis that BDV is associated with human illness is controversial. However, should even a small fraction of mental illness be attributable to infection with BDV, this would be an important finding, not least because illness in that sub-population would, theoretically, be preventable. METHODS: We systematically reviewed the evidence: that BDV infects humans; for the role of BDV in human neuropsychiatric illness; to assess the suitability of currently available laboratory methods for human epidemiological studies. RESULTS: We identified 75 documents published before the end of January 2000, describing 50 human studies for BDV. There were five case studies and 44 (sero)prevalence studies, in a variety of patient groups. Nineteen prevalence studies (43%) investigated seroprevalence, 11 (25%) investigated viral prevalence and 14 (32%) investigated both. Seroprevalence ranged from 0% to 48%, and prevalence of virus or viral footprints from 0% to 82%. DISCUSSION: Although agreed gold standard tests and evidence for test specificity are lacking, there is evidence that humans are exposed to the virus. Further epidemiological studies are required to establish whether there are associations with disease.

Publication Types:

• Review

I figure that I've always been totally fucked when it comes to just about everything. But I've been reading about some new reseach and I thought I'd just collect it here on this blog.

this gun is not a toy
this gun is for your protection
this gun is to be kept with and you are responsible for
this gun was made in a factory by factory workers and
this gun has been inspected, sold and approved by everyone

this gun should not be tampered with
this gun should be kept nice to insure proper performance
this gun can be effective when used one yourself. hold
this gun to your head in a well lit area and pull the trigger of
this gun and things will change
this gun will be sold

A
Maimed
shroud
wavers
exponentailly
indarkslightair

I can't see
through
anything

But

It doesn't stop
meandering vigourously
toward me

Stack and stacks
of it

good heavens

Treasonous portions
Hacked through a thick wall

Insufferable vixens
Prance in Predawn
Dewbeds

Then
Rushing ever nearer
"Skim, Skim,Skim"
A
Dancing Parody
A
scheme of derelict momentum
A
deference cresting
about the jaded vanquished

godman

yoked foe

excessive posturing fiend

A seething falsehood
thrust up then over
In a foremost
cognative
pounce

October 13, 2004

Dear Sir or Madam:

At or around 12:30 today I was working at my job as a personal Care Assistant for The Cornerstone Foundation In their Day Service Facility( this is the place where all the special needs clients stay for the day and have classes and activities).   Lunch had been served and I was I was waiting to go on what they call the work program which consists of supervising the higher functioning residents as they work on the owners ranch or take care of  the residential homes owned by the foundation.  There are no scheduled breaks or lunches at the facility and it is up to the staff to provide themselves break time during the day during slow periods.  I had just finished lunch while helping the other staff supervise the meals.  I then took the time to go outside to have a break.  As staff is required to be in the smoking room when residents are present I took it upon my self to watch the unsupervised residents that I found in the break room.  I remember that one resident whose name was Jeanne was causing a commotion by saying unpleasant things to another resident whose name is George.  Since I had worked at this facility I had found that Jeanne had a very labile mood.  She would often make very derogatory remarks to both patients and staff.  These remarks were often ignored by the staff and this action would either spur her one to make more cutting remarks or to be quiet.  As I could never determine the cause of her agitation I chose to ignore her remarks.   She did however escalate in my case by physically striking me and pulling my hair on more than one occasion.  In the Smoking room I did notice that Jeanne and George were agitated and arguing about something.  I assumed that Jeanne had said something that annoyed George and George was trying to defuse the situation as best he could.  Since this is a common occurrence I was not paying particular attention to their argument as I was talking to another client named Jackson.  I heard one person who I am not sure was staff or another client tell George that you’re better off ignoring her.  This is the last thing I remember of the incident.  A bit later a staff member named Penny came into the room and asked me and George to come with her.  We were led into the office that is used by Tish and Rick.  Rick and Tish and I believe Penny and a blonde haired lady who is newly designated director of the residential program were in the room.  Jim Starr had and a resident had been asked to leave.  The door was shut and Rick asked us who wanted to start.  I had no knowledge of what he was talking about so I remained silent. George also remained silent.  Rick then directed his attention to George and asked him why he told Jeanne to suck his big fat dick.  Rick did not what for a reply and asked what he thought his punishment should be.  George said that he could forgo outings but Rick said that wasn’t enough and he warned George that if he did not come up with a suitably harsh punishment for himself that he would regret it.  George then offered to quit smoking for one and then two weeks which Rick then accepted.  Rick went on to say that he had been warned on numerous occasions that he could not swear and that he would have to sit with Rick in his office during breaks.  He told George that if it happened again he would take away his holiday visits to his family and have him spend Christmas with him.  Rick then dismissed George and turned his attention to me.  He told me that another staff had heard me laugh at Georges comment to Jeanne and asked me what I had to say for my self.  I said I didn’t remember him saying that.  He said that I must have remembered since it had happened within the last five minutes.  I said I was sorry but I didn’t remember the incident.  He stated that I must be either dumb or lying.  At this point I found my self wondering why this man was so angry with me.  He then asked me if he gave me a paycheck each week for working there.  I said yes he did. He said that I was fucking working for him and that meant I needed to supervise the residents.  I stated that I didn’t think it was appropriate for him to talk to me in that manner and asked if he wanted to fire me.  He told me that that would be too good for me since I could then get unemployment insurance.  He then threatened to find some other way to fire me without having to pay me unemployment insurance.  As my knowledge of the unemployment insurance laws of this state are vague at best I did not know what he was specifically talking about.  I do know that I had been working there for almost a year and had been never written up and had a very good attendance record  along  with a good review he had no common ground to fire me.  I therefore felt threatened and when he asked if I had anything more to say I said I resign and walked out.        

Sincerely,